So, you’re wondering about the Colemak keyboard layout? It’s actually not that esoteric, it’s designed to be almost like QWERTY but with only a few modifications.
20180726/https://en.wikipedia.org/wiki/Colemak
20180726/https://colemak.com/
There is a user community with good things to say about this and discuss about this.
20180726/https://forum.colemak.com/
20180726/https://forum.colemak.com/forum/6-experiences/
20180726/https://forum.colemak.com/topic/2393-colemak-from-30-years-of-qwerty-110wpm/
Keyboard layouts general Wikipedia page.
20180726/https://en.wikipedia.org/wiki/Keyboard_layout
And an interesting idea after reading about overlay keyboards. So, you want a keyboard where it is easy to change the printed letter keycaps on demand? Well, you can print sheets of paper and put them on top, or you can re-arrange the keycaps when you have a removable keycaps keyboard.
Now, here’s my other own idea. You can use a videoprojector to project the keys onto the keyboard, then changing them in software is easy and quick.
20180726/https://en.wikipedia.org/wiki/Overlay_keyboard